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He said of his character, Tommy D., "There's a sense of anxiety that runs through these kids, especially Tommy, because he's so sensory and feeling and animalistic, that's my perspective of him." He further remarked that the scenes in which his character—unable to contain his frustration—erupts with a wail, were "intense" for him.
"I think those screams are inside all of us, I just got a chance to let mine out".
The film's arduous principal photography took place in Taiwan and to achieve his character's physicality, Garfield lost 40 pounds.
Kate Taylor of The Globe and Mail disliked the film and wrote that Garfield "is sweetly resolute and gently anguished as the missionary Rodrigues but any hope that the actor might elucidate the psychology of philosophical certitude or the pain of religious doubt proves vain".
In preparation, he interacted with victims of the disease and collaborated closely with Cavendish's wife and son.
Stephen Dalton of The Hollywood Reporter wrote that despite an exceptional story, the film had glossed over the complexities in Cavendish's life, and thought that Garfield was "hampered by a role that restricts him to little more than nodding and grinning".
It was directed by Marianne Elliott and co-starred Nathan Lane, James Mc Ardle, Russell Tovey and Denise Gough.
In 2010, Garfield co-starred opposite Carey Mulligan and Keira Knightley in Mark Romanek's dystopian science fiction drama Never Let Me Go, an adaptation of Kazuo Ishiguro's 2005 novel of the same name.
In 2016, Garfield starred in two critically acclaimed historical dramas, Hacksaw Ridge and Silence. Doss in the former earned him nominations for the Academy Award and BAFTA Award for Best Actor.
On stage, Garfield has played Biff in a 2012 Broadway revival of Arthur Miller's play Death of a Salesman, which earned him a Tony Award nomination for Best Featured Actor in a Play.
The same year, Garfield co-starred opposite Jesse Eisenberg in The Social Network, a drama based on the founders of Facebook.
On his character, Garfield remarked that "No one knows who Eduardo Saverin is, and I don't either.